Manufacturing Supervisor, NGS TE Production

About the role

The Manufacturing Supervisor, NGS TE Production will bring strong knowledge of synthetic and molecular biology techniques, including PCR, vector production, cloning, miniprep, DNA analysis, sequencing, and packaging. In this role, you’ll perform, train, and oversee production staff on molecular biology workflows in a highly automated, high-throughput environment, and you’ll be responsible for manufacturing and analyzing a variety of custom gene products across Twist Bioscience’s proprietary workflow according to SOPs and the daily production schedule.

As the main point of contact for shift operators, you’ll make sure the shift team is working to the plan of record, provide guidance, set priorities, and lead troubleshooting. You’ll also lead the pass-down of information between shifts.

The ideal candidate works independently, is highly organized, has excellent molecular biology skills, maintains and builds 5S systems, contributes to process improvement and documentation, and communicates effectively with peers and management. You’ll have knowledge of good laboratory practices (GLPs), familiarity with GMP or ISO-rated production, and experience leading and training others. You must be comfortable working in a LEAN manufacturing, controlled laboratory environment.

Shift 2B: Wednesday-Friday w/alt Saturday 7:00pm-7:30am

What You’ll Be Doing

Manufacture high-quality custom gene products in a high-throughput manufacturing lab according to established SOPs

Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations

Operate semi-automated and automated lab equipment for molecular biology workflows

Track metrics on product quality using both physical and functional test methods

Apply scientific principles to problem-solve and troubleshoot test results

Proactively identify production problems and recommend solutions for lab techniques, protocols, processes, and product and equipment handling

Uphold standards defined by the manufacturing process

Support continuous cost and process improvement initiatives

Work safely at all times

Maintain and calibrate select lab equipment

Lead shift pass-down efforts and prioritize workflows

Take accountability for the shift when senior personnel are not on site

Advise on meeting schedules and resolving technical problems, and provide production guidance to junior manufacturing staff

Schedule staff

Review and verify production batch records and manufacturing documents

Write and submit incident reports, CAPAs, planned deviations, and related documentation

Follow regulatory and ISO 13485 requirements

What You’ll Bring to the Team

A.S. or B.S. in Biology, Chemistry, or Biochemistry

Minimum of 5 years of lab experience in a manufacturing environment

Experience operating liquid handlers such as Hamilton and Tecan

Experience with instrumentation for PCR, cell-based cloning, miniprep extraction, and purification is a huge plus

Experience with sample tracking software and with interfaces between robotic instrumentation and LIMS/MES systems

Experience working in ISO, GMP, and LEAN manufacturing environments and applying lean manufacturing concepts

Excellent scientific computation and data analysis skills

Experience assessing current processes and techniques and implementing procedural improvements

Experience leading small teams in a laboratory environment

Strong problem-solving and communication skills

Ability to stand for long periods while performing duties

Ability to work safely with chemicals and hazardous materials

Ability to lift up to 20 lbs

Ability to work outside regular hours or a flexible shift as needed

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law. The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations. San Francisco Bay Area Pay Range $45—$50 USD